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What is Cartrophen Vet and how does it work?

Cartrophen Vet is a revolutionary advance in the treatment for arthritis in dogs. In fact millions of dogs enjoy the benefits of this superior and tested technology with it continuing to treat millions of dogs after 20 years of use in the treatment of arthritis in dogs.

Cartrophen Vet (100mg/mL pentosan polysulfate sodium) is a prescription only, injectable, sulphated sugar of plant origin. It has many sites of action within the underlying processes of the arthritis disease which helps maintain joint health, including preserving joint cartilage. It is therefore classified as a disease modifying osteoarthritis drug (DMOAD).


The treatment

Cartrophen Vet is an injection given by your vet in a similar way to a vaccine with four weekly doses. This is a convenient way to ensure that your pet receives the appropriate dosage without daily regimen. It is essential that your dog complete all 4 injections to ensure optimal benefit and modification of the disease process.

80% of pets respond quickly to the initial course (Francis and Read, 1993; Cullis-Hill and Ghosh, 1994; Bouck et al, 1995; Read et al, 1996; Smith et al 2001) with a reduction in lameness and pain and a subsequent increase in activity and well-being.

The frequency of treatment varies from once a year for mild cases and up to three times a year for severe cases.

Your veterinarian may vary this regimen to obtain the optimum reduction of arthritic symptoms.


How does Cartrophen Vet work?

Cartrophen Vet works to modify the underlying arthritic processes to relieve pain and lameness. Improvements from Cartrophen Vet result in long-term effects lasting beyond the treatment period of 4 weeks (Smith et al., 2001), up to one year in some cases.

Cartrophen Vet has been shown to exhibit the following modes of action

  1. Stopping the destructive enzymes that break down cartilage, which is the body's natural shock absorber (Rogachefsky et al., 1993)
  2. Stimulate the body's production of cartilage (Rogachefsky et al., 1993)
  3. Stimulate the body's production of joint lubricant (Francis et al., 1993)
  4. Clear the blockages in blood vessels to deliver nutrition to the joint and bone (Ghosh and Cheras, 2001)
  5. Stimulate the production of anti-oxidants that block damaging free radicals (Bowman et al.,1994)

 

REFERENCES

Bouck GR, Miller CW and Taves CL (1995). A comparison of surgical and medical treatment of fragmented coronoid process and osteochondritis dissecans of the canine elbow. V.C.O.T. 8: 177-183

Bowman L, et al. (1994) Calcium pentosan polysulphate (CaPPS) stimulates release of superoxide dismutase (SOD) from endothelium in vitro and in vivo. Int. Soc. Free Radical Res., 7th Biennial Meeting 1994

Cullis-Hill D and Ghosh P (1994). Joint Convention of L'Ordre des. Medicins veterinaries du Quebec and the Canadian Veterinary Medical Association, Quebec City, Canada, July 6-9

Francis DJ, Hutadilok N, Kongtawelert P, Ghosh P (1993) Pentosan polysulphate and glycosaminoglycan polysulphate stimulate the synthesis of hyaluronan in vivo. Rheumatol Int 13:61-64

Francis DJ and Read RA (1993). Pentosan polysulphate as a treatment for osteoarthritis (degenerative joint disease) in dogs. Aust. Vet. Practit. 23(2):104-109

Ghosh P and Cheras PA (2001). Vascular mechanisms in osteoarthritis. Best Pract. Res. Clin. Rheumatol. 15(5): 693-710

Read RA, Cullis-Hill D and Jones MP (1996). Systemic use of pentosan polysulfate in the treatment of osteoarthritis. J.Small Anim Pract. 37: 108-114

Rogachefsky RA, Dean DD, Howell DS, Altman RD (1993) Treatment of canine osteoarthritis with insulin-like growth factor-1 (IGF-1) and sodium pentosan polysulfate. Osteoarthritis Cart 1:105-114

Smith JG, Hannon RL, Brunnberg L, Gebski V, Cullis-HiII D (2001) A Randomised double blind comparator clinical study of the efficacy of sodium pentosan Polysulfate injection and carprofen capsules in arthritic dogs, Journal of the Osteoarthritis Research Society International, 9(b):S21-S22